Fonchy E, Lahrech H, François-Joubert A, Dupeyre R, Benderbous S, Corot C, Farion R, Rubin C, Décorps M, Rémy C
Unité mixte INSERM/Université Joseph Fourier, RMN Bioclinique U 438, LRC-CEA, Hôpital Albert Michallon, Grenoble, France.
J Magn Reson Imaging. 2001 Aug;14(2):97-105. doi: 10.1002/jmri.1158.
T1-weighted magnetic resonance imaging (MRI) was used to evaluate the potential interest of a new Gd-based contrast agent, termed P760, to characterize brain tumor heterogeneity and vascularization and to delineate regions containing permeable vessels. The C6 rat glioma model was used as a model of high-grade glioblastoma. The signal enhancement was measured as a function of time in the vascular compartment and in different regions of interest (ROIs) within the tumor after the injection of 0.02 mmol x kg(-1) of P760. The results were compared to those obtained after the injection of 0.1 mmol x kg(-1) of Gd-DOTA. We showed that P760, in spite of a Gd concentration five times smaller, produces an enhancement in the blood pool similar to that produced by Gd-DOTA. It was shown that P760 makes possible an excellent delineation of regions containing vessels with a damaged blood-brain barrier (BBB). Images acquired 5-10 minutes after P760 injection showed the location of permeable vessels more accurately than Gd-DOTA-enhanced images. The enhancement produced in the tumor by P760 was, however, less than that produced by Gd-DOTA. The extravasation and/or diffusion rate of P760 in the interstitial medium were found to be strongly reduced, compared to those found with Gd-DOTA. This study suggests that the new contrast agent has promising capabilities in clinical imaging of brain tumors.
采用T1加权磁共振成像（MRI）评估一种名为P760的新型钆基造影剂在表征脑肿瘤异质性和血管化以及描绘含有可渗透血管区域方面的潜在价值。将C6大鼠胶质瘤模型用作高级别胶质母细胞瘤的模型。在注射0.02 mmol·kg⁻¹的P760后，测量血管腔室以及肿瘤内不同感兴趣区域（ROI）的信号增强随时间的变化。将结果与注射0.1 mmol·kg⁻¹的钆喷酸葡胺（Gd-DOTA）后获得的结果进行比较。我们发现，尽管P760的钆浓度低五倍，但它在血池中的增强效果与Gd-DOTA产生的增强效果相似。结果表明，P760能够出色地描绘出具有受损血脑屏障（BBB）的血管区域。注射P760后5 - 10分钟采集的图像比Gd-DOTA增强图像更准确地显示了可渗透血管的位置。然而，P760在肿瘤中产生的增强效果小于Gd-DOTA。与Gd-DOTA相比，发现P760在间质介质中的外渗和/或扩散速率大大降低。这项研究表明，这种新型造影剂在脑肿瘤临床成像方面具有广阔的应用前景。
