Xu L, Liu P, Yan D
Qingdao Family Planing Research Institute, Qingdao 266071.
Zhonghua Fu Chan Ke Za Zhi. 1999 Oct;34(10):591-3.
To investigate the relationship between endothelin-1 (ET-1) concentration in amniotic fluid (AF) and perinatal hypoxia.
161 cases were measured for amniotic fluid(AF) ET-1 levels by radioimmunoassay. 110 cases of normal pregnancy were included in control group among which 30 term pregnancies were simultaneously measured for maternal and umbilical plasma ET-1. 51 cases of intrauterine hypoxia were the study group.
(1) The AF ET-1 levels showed increasing trend after 14 weeks (P < 0.01). (2) Fetal plasma ET-1 levels were significantly higher than that of maternal plasma ET-1 levels, but lower than those of AF ET-1 (P < 0.01). The ET-1 levels of umbilical plasma had positive correlation with those of AF ET-1 (r = 0.952, P < 0.01), but there is no correlation with levels of maternal plasma ET-1 (r = 0.338, P < 0.05). (3) In study group, the level of AF ET-1 was elevated with severity of hypoxia, the average level of AF ET-1 in cases of intrauterine hypoxia was (30.654 +/- 5.832) ng/L. In cases of severe neonatal asphyxia it was (960.650 +/- 236.698) ng/L.
The ET-1 exists in AF and gradually increases while pregnancy advanced. AF ET-1 levels can be served as a marker to predict perinatal hypoxia.
探讨羊水内皮素 -1（ET -1）浓度与围产期缺氧的关系。
采用放射免疫法测定161例孕妇羊水ET -1水平。对照组纳入110例正常妊娠孕妇，其中30例足月妊娠孕妇同时测定母血和脐血血浆ET -1。研究组为51例宫内缺氧孕妇。
（1）孕14周后羊水ET -1水平呈上升趋势（P < 0.01）。（2）胎儿血浆ET -1水平显著高于母血血浆ET -1水平，但低于羊水ET -1水平（P < 0.01）。脐血血浆ET -1水平与羊水ET -1水平呈正相关（r = 0.952，P < 0.01），与母血血浆ET -1水平无相关性（r = 0.338，P < 0.05）。（3）研究组中，羊水ET -1水平随缺氧程度加重而升高，宫内缺氧孕妇羊水ET -1平均水平为（30.654 ± 5.832）ng/L。重度新生儿窒息孕妇羊水ET -1平均水平为（960.650 ± 236.698）ng/L。
ET -1存在于羊水中，且随孕周增加而逐渐升高。羊水ET -1水平可作为预测围产期缺氧的指标。
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