Zamłyński Jacek, Chudek Jerzy, Olejek Anita, Kobylec-Zamłyńska Barbara, Mańka Grzegorz, Bodzek Piotr, Wiecek Andrzej
Department of Obstetrics, Gynaecology and Gynaecological Oncology, Medical University of Silesia, Bytom, Poland.
Gynecol Endocrinol. 2007 May;23(5):295-9. doi: 10.1080/09513590701281405.
Galanin is a hypothalamic regulatory peptide involved in the regulation of appetite. It is synthesized by the nervous system, anterior pituitary gland, adrenal medulla, pancreas, intestine and placenta. Placental secretion of galanin has until now only been investigated in animals. Additionally, galanin concentration has not been assessed in umbilical cord blood and amniotic fluid.
Galanin concentrations were measured in maternal circulation before term delivery, in cord blood and in amniotic fluid of 45 healthy pregnant women (gestational age 38 - 40 gestational weeks). The control group consisted of 26 normally menstruating healthy women.
Plasma galanin concentrations were found to be similar in pregnant healthy women before term delivery (20.8 +/- 1.9 pg/ml) and non-pregnant women (19.0 +/- 1.7 pg/ml). Galanin concentration in umbilical cord blood (26.5 +/- 2.2 pg/ml) was significantly higher (p < 0.05) than in maternal circulation. Galanin concentration in amniotic fluid (20.4 +/- 1.0 pg/ml) was similar to that observed in maternal plasma, but significantly (p < 0.01) lower than in umbilical cord blood. A significant correlation was found between maternal body mass index and plasma galanin concentration (tau = 0.246; p < 0.05) and between birth weight and cord blood galanin concentration (tau = 0.345; p = 0.01). There was no significant correlation between placental mass and cord blood galanin concentration (tau = 0.124; p = 0.26).
Plasma galanin concentration in pregnant women before term delivery is similar to that in non-pregnant women. The fetus rather than the placenta is the source of the high galanin concentration in umbilical cord blood. The role of galanin in the regulation of newborn weight is uncertain.
甘丙肽是一种参与食欲调节的下丘脑调节肽。它由神经系统、垂体前叶、肾上腺髓质、胰腺、肠道和胎盘合成。迄今为止，仅在动物中研究了胎盘分泌的甘丙肽。此外，尚未评估脐血和羊水中的甘丙肽浓度。
测量了45名健康孕妇（孕周38 - 40周）足月分娩前母血循环、脐血和羊水中的甘丙肽浓度。对照组由26名月经正常的健康女性组成。
发现足月分娩前健康孕妇血浆甘丙肽浓度（20.8±1.9 pg/ml）与非孕妇（19.0±1.7 pg/ml）相似。脐血中甘丙肽浓度（26.5±2.2 pg/ml）显著高于母血循环（p < 0.05）。羊水中甘丙肽浓度（20.4±1.0 pg/ml）与母血血浆中观察到的浓度相似，但显著低于脐血（p < 0.01）。发现孕妇体重指数与血浆甘丙肽浓度之间存在显著相关性（tau = 0.246；p < 0.05），出生体重与脐血甘丙肽浓度之间也存在显著相关性（tau = 0.345；p = 0.01）。胎盘重量与脐血甘丙肽浓度之间无显著相关性（tau = 0.124；p = 0.26）。
足月分娩前孕妇血浆甘丙肽浓度与非孕妇相似。脐血中高浓度甘丙肽的来源是胎儿而非胎盘。甘丙肽在新生儿体重调节中的作用尚不确定。
