Armstrong M D, Klein J R
Department of Biological Science and the Mervin Bovaird Center for Studies in Molecular Biology and Biotechnology, University of Tulsa, OK, USA.
Arch Immunol Ther Exp (Warsz). 2001;49(3):231-7.
The immune and neuroendocrine systems are two essential physiological components of mammalian organisms. Although each is primarily committed to a set of tasks involved, on the one hand, in the protection from infection and disease, and on the other hand, in the regulation of metabolism and other physiological activities, there is also evidence indicating that active and dynamic collaborations exist between those systems in the execution of their designated functions. These interactions occur at many stages of embryonic and neonatal development, and they are a continual part of the normal homeostatic balance needed to maintain health. The present review discusses various historical and contemporary perspectives of immune-endocrine interactions involving the hypothalamus-pituitary-thyroid axis, and offers a hypothesis of how this aspect of the neuroendocrine system participates directly in the immune response to antigenic challenge, infection and disease.
免疫系统和神经内分泌系统是哺乳动物机体的两个重要生理组成部分。虽然它们各自主要负责一系列任务，一方面是预防感染和疾病，另一方面是调节新陈代谢及其他生理活动，但也有证据表明，在执行其指定功能时，这些系统之间存在积极且动态的协作。这些相互作用发生在胚胎和新生儿发育的许多阶段，并且是维持健康所需的正常稳态平衡的持续组成部分。本综述讨论了涉及下丘脑 - 垂体 - 甲状腺轴的免疫 - 内分泌相互作用的各种历史和当代观点，并提出了一个关于神经内分泌系统这一方面如何直接参与对抗抗原挑战、感染和疾病的免疫反应的假说。
