从文库中发现的先导化合物。

Lead compounds discovered from libraries.

作者信息

Golebiowski A, Klopfenstein S R, Portlock D E

机构信息

Procter & Gamble Pharmaceuticals, Health Care Research Center 45040-8006, Mason, OH, USA.

出版信息

Curr Opin Chem Biol. 2001 Jun;5(3):273-84. doi: 10.1016/s1367-5931(00)00203-9.

DOI:10.1016/s1367-5931(00)00203-9

PMID:11479119

Abstract

Lead compounds with the potential to progress to viable drug candidates have been identified from libraries using several strategies. These include rapid screening of large diverse collections, thematic libraries, project-directed libraries, and three-dimensional molecular models of corporate databases. There have been numerous success stories, including the identification of several clinical candidates.

摘要

已通过多种策略从文库中鉴定出有潜力发展成为可行药物候选物的先导化合物。这些策略包括对大量不同化合物库、主题文库、项目导向文库以及公司数据库的三维分子模型进行快速筛选。已有众多成功案例，包括鉴定出多个临床候选药物。