CuI nanoparticle-catalyzed synthesis of tetracyclic benzo[]benzo[4,5]imidazo[1,2-][1,3]thiazin-6-imine heterocycles by SAr-type C-S, C-N bond formation from isothiocyanatobenzenes and benzimidazoles.

In this paper, a simple and practical synthesis of benzo[]benzo[4,5]imidazo[1,2-][1,3]thiazin-6-imine tetracyclic heterocycles a CuI nanoparticle-catalyzed intramolecular C(sp)-S coupling reaction is presented. This strategy provides a straightforward method for synthesizing analogs of the anti-HIV drug 3,4-dihydro-2,6-pyrimido[1,2-][1,3]benzothiazin-6-imine (PD 404182). The reaction rate and yield were increased by employing CuI nanoparticles.