一项针对西班牙儿童幽门螺杆菌对克拉霉素和甲硝唑耐药性的9年研究。

A 9 year study of clarithromycin and metronidazole resistance in Helicobacter pylori from Spanish children.

作者信息

López-Brea M, Martínez M J, Domingo D, Alarcón T

机构信息

Department of Microbiology, Hospital Universitario de la Princesa, Diego de León 62, 28006 Madrid, Spain.

出版信息

J Antimicrob Chemother. 2001 Aug;48(2):295-7. doi: 10.1093/jac/48.2.295.

DOI:10.1093/jac/48.2.295

PMID:11481305

Abstract

The evolution of clarithromycin, metronidazole and amoxycillin resistance in 246 Spanish Helicobacter pylori clinical isolates, obtained from paediatric patients during a 9 year period, was determined by an agar dilution technique. Clarithromycin resistance (MIC 1 mg/L) was 2.27% (IC95 0.05-12.02) in 1991-1993, 20.98% (IC95 12.72-31.46) in 1994-1996 and 28.33% (IC95 20.48-37.28) in 1997-1999 (P < 0.01). Metronidazole resistance (MIC 8 mg/L) was 7.14% (IC95 1.49-19.48) in 1991-1993, 20.25% (IC95 12.04-30.79) in 1994-1996 and 43.90% (IC95 32.95-55.30) in 1997-1999 (P < 0.01). Amoxycillin resistance was not found (all strains showed MICs < 2 mg/L).

摘要

采用琼脂稀释法测定了9年间从西班牙儿科患者中分离出的246株幽门螺杆菌临床分离株对克拉霉素、甲硝唑和阿莫西林的耐药性演变情况。1991 - 1993年克拉霉素耐药率（MIC≥1mg/L）为2.27%（95%置信区间0.05 - 12.02），1994 - 1996年为20.98%（95%置信区间12.72 - 31.46），1997 - 1999年为28.33%（95%置信区间20.48 - 37.28）（P < 0.01）。1991 - 1993年甲硝唑耐药率（MIC≥8mg/L）为7.14%（95%置信区间1.49 - 19.48），1994 - 1996年为20.25%（95%置信区间12.04 - 30.79），1997 - 1999年为43.90%（95%置信区间32.95 - 55.30）（P < 0.01）。未发现阿莫西林耐药情况（所有菌株MIC均<2mg/L）。