多个转录因子基因是光敏色素A信号传导的早期靶标。
Multiple transcription-factor genes are early targets of phytochrome A signaling.
作者信息
Tepperman J M, Zhu T, Chang H S, Wang X, Quail P H
机构信息
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.
出版信息
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9437-42. doi: 10.1073/pnas.161300998.
The phytochrome family of sensory photoreceptors directs adaptational changes in gene expression in response to environmental light signals. Using oligonucleotide microarrays to measure expression profiles in wild-type and phytochrome A (phyA) null-mutant Arabidopsis seedlings, we have shown that 10% of the genes represented on the array are regulated by phyA in response to a continuous far-red light signal. Strikingly, 44% of the genes responding to the signal within 1 h are predicted to encode multiple classes of transcriptional regulators. Together with previous data, this observation suggests that phyA may regulate seedling photomorphogenesis by direct targeting of light signals to the promoters of genes encoding a master set of diverse transcriptional regulators, responsible in turn for orchestrating the expression of multiple downstream target genes in various branches of a phyA-regulated transcriptional network.
光敏色素家族的感光光受体可根据环境光信号引导基因表达的适应性变化。我们利用寡核苷酸微阵列来测量野生型和光敏色素A（phyA）缺失突变体拟南芥幼苗的表达谱，结果表明，阵列上10%的基因受phyA调控，以响应持续的远红光信号。引人注目的是，在1小时内对该信号作出反应的基因中，44%预计编码多种类型的转录调节因子。结合先前的数据，这一观察结果表明，phyA可能通过将光信号直接靶向编码一组主要的不同转录调节因子的基因启动子，来调节幼苗的光形态建成，而这些转录调节因子又负责协调phyA调控的转录网络各个分支中多个下游靶基因的表达。
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