胰岛素样生长因子结合蛋白2及IGF-Ⅰ型受体阻断抗体对人畸胎瘤细胞体外凋亡的影响
Effects of insulin-like growth factor-binding protein 2 and an IGF-type I receptor-blocking antibody on apoptosis in human teratocarcinoma cells in vitro.
作者信息
Granerus M, Engström W
机构信息
Department of Pathology, Swedish University of Agricultural Sciences, Uppsala, S-750 07, Sweden.
出版信息
Cell Biol Int. 2001;25(8):825-8. doi: 10.1006/cbir.2001.0756.
PMID:11482908
Abstract
Human teratocarcinoma cells (Tera-2) deprived of serum undergo programmed cell death which can be counteracted by simultaneous addition of IGF-I or IGF-II. This protective effect of IGFs was specific in the sense that both addition of IGF-binding protein-2, and blocking of the IGF-type I receptor by a specific antibody, both resulted in an increased apoptotic rate.
摘要
缺乏血清的人畸胎瘤细胞（Tera-2）会经历程序性细胞死亡，而同时添加胰岛素样生长因子-I（IGF-I）或胰岛素样生长因子-II（IGF-II）可抵消这种死亡。IGFs的这种保护作用具有特异性，因为添加胰岛素样生长因子结合蛋白-2以及用特异性抗体阻断IGF-I型受体均会导致凋亡率增加。
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