由N-炔丙基酰胺制备2,5-二取代恶唑
Preparation of 2,5-disubstituted oxazoles from N-propargylamides.
作者信息
Arcadi A, Cacchi S, Cascia L, Fabrizi G, Marinelli F
机构信息
Dipartimento di Chimica Ingegneria Chimica e Materiali della Facoltà di Scienze, Università de L'Aquila, Via Vetoio, Coppito Due, I-67100 L'Aquila, Italy.
出版信息
Org Lett. 2001 Aug 9;3(16):2501-4. doi: 10.1021/ol016133m.
PMID:11483045
Abstract
[reaction: see text] 2,5-Disubstituted oxazoles have been prepared through the reaction of N-propargylamides with aryl iodides in the presence of Pd(2)(dba)(3), tri(2-furyl)phosphine, and NaO(t)()Bu. The reaction appears to proceed through a palladium-catalyzed coupling step followed by the in situ cyclization of the resultant coupling product.
摘要
[反应：见正文] 通过N-炔丙基酰胺与芳基碘化物在Pd(2)(dba)(3)、三(2-呋喃基)膦和叔丁醇钠存在下反应制备了2,5-二取代恶唑。该反应似乎通过钯催化的偶联步骤进行，随后所得偶联产物进行原位环化。
Zotero 插件