[激光偏振仪分析年龄相关的神经纤维层厚度变化]

[Analysis of aged-related nerve fiber layer thickness changes with laser polarimetry].

作者信息

García Feijoó J, García Sánchez J

机构信息

Hospital Clínico San Carlos, Madrid.

出版信息

Arch Soc Esp Oftalmol. 2001 Aug;76(8):477-83.

PMID:11484141

Abstract

PURPOSE

Scanning laser polarimetry allows a quantitative study of the retinal nerve fiber layer thickness. It was used to evaluate the effects of aging on thickness of nerve fiber layer in the retinal of normal subjects.

METHODS

The retinal nerve fiber layer thickness of 48 eyes of 48 normal subjects was studied. Three consecutive polarimetric images were acquired for each eye and the mean image was calculated, the nerve fiber layer thickness measurements was obtained in this image using the standard 10 pixels and 1.75 disc diameter band centered on the optic nerve head. The standard GDx quadrants were used. Linear regression analysis was used to evaluate the effects of aging on the nerve fiber layer thickness.

RESULTS

The mean nerve fiber layer thickness was 78.59 SD 9.81 microm. A significant reduction with age was found in the mean nerve fiber layer thickness (r2: 0.19, p=0.002), the mean superior-inferior quadrant thickness (r2: 0.239, p<0.001), the superior (r2: 0.212; p=0.001) and inferior quadrant thickness (r2: 0.196, p= 0.002), and the maximal superior quadrant (r2: 0.111, p= 0.019) and inferior quadrant thickness (r2: 0.081, p=0,048).

CONCLUSIONS

The nerve fiber layer thickness decreases with increasing age in normal subjects.

摘要

目的

扫描激光偏振仪可对视网膜神经纤维层厚度进行定量研究。本研究旨在评估衰老对正常受试者视网膜神经纤维层厚度的影响。

方法

对48名正常受试者的48只眼睛的视网膜神经纤维层厚度进行研究。每只眼睛连续采集三张偏振图像并计算平均图像，使用以视乳头为中心的标准10像素和1.75视盘直径带在该图像中测量神经纤维层厚度。采用标准的GDx象限。使用线性回归分析评估衰老对神经纤维层厚度的影响。

结果

神经纤维层平均厚度为78.59±9.81微米。发现神经纤维层平均厚度（r2：0.19，p = 0.002）、平均上下象限厚度（r2：0.239，p < 0.001）、上象限（r2：0.212；p = 0.001）和下象限厚度（r2：0.196，p = 0.002），以及最大上象限（r2：0.111，p = 0.019）和下象限厚度（r2：0.081，p = 0.048）均随年龄显著降低。