Terme M, Masurier C, Fernandez N, Lacassagne M N, Marolleau J P, Zitvogel L
Pathol Biol (Paris). 2001 Jul;49(6):475-7. doi: 10.1016/s0369-8114(01)00170-5.
CD8+ cytotoxic T lymphocytes (CTL), specifically directed against tumor-associated antigens, can be used in immunotherapy as effector cells in order to induce antitumor immune response. However, natural killer (NK) cells, that belong to the innate immune system, might also play a role on the anti-tumoral immune response. Our data show that quiescent NK cells can be activated by direct cell contact with dendritic cells (CD). Such a NK cells activating ability places DC at the frontier between innate and cognate immunity and then may encourage their use in clinical trials designed to elicit both CTL and NK responses.
针对肿瘤相关抗原的CD8 + 细胞毒性T淋巴细胞（CTL）可作为效应细胞用于免疫治疗，以诱导抗肿瘤免疫反应。然而，属于先天免疫系统的自然杀伤（NK）细胞也可能在抗肿瘤免疫反应中发挥作用。我们的数据表明，静止的NK细胞可通过与树突状细胞（DC）直接接触而被激活。NK细胞的这种激活能力使DC处于先天免疫和适应性免疫的前沿，进而可能促使其在旨在引发CTL和NK反应的临床试验中得到应用。
