Dalwadi H, Wei B, Kronenberg M, Sutton C L, Braun J
Department of Pathology and Laboratory Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA.
Immunity. 2001 Jul;15(1):149-58. doi: 10.1016/s1074-7613(01)00164-9.
An aberrant T cell response to enteric bacteria is important in inflammatory bowel disease. However, the identity of relevant microbial antigens is unknown. Here, we report the presence of I2, a Crohn's disease-associated microbial gene, in the murine intestine. The I2 protein induced a proliferative and IL-10 response by CD4(+) T cells from unimmunized mice. The I2 response was dependent on MHC class II-mediated recognition but did not require antigen processing. Selective activation was observed for the TCR-Vbeta5 subpopulation. These findings indicate that the I2 protein is a new class of T cell superantigen and suggest that colonization by the I2 microorganism in susceptible hosts may provide a superantigenic stimulus pertinent to Crohn's disease pathogenesis.
肠道细菌引发的异常T细胞反应在炎症性肠病中具有重要作用。然而，相关微生物抗原的具体身份尚不清楚。在此，我们报告在小鼠肠道中存在一种与克罗恩病相关的微生物基因I2。I2蛋白可诱导未免疫小鼠的CD4(+) T细胞产生增殖反应并分泌白细胞介素-10。I2引发的反应依赖于MHC II类分子介导的识别，但不需要抗原加工过程。我们观察到TCR-Vbeta5亚群的选择性激活。这些发现表明I2蛋白是一类新型的T细胞超抗原，并提示I2微生物在易感宿主中的定植可能提供与克罗恩病发病机制相关的超抗原刺激。
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