Kronenberg A, Seebach J D, Bossart W, Weber R
Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zürich, Zürich, Switzerland.
Clin Infect Dis. 2001 Sep 1;33(5):E34-6. doi: 10.1086/322652. Epub 2001 Jul 30.
We report the first case of a patient infected with HIV in whom polyclonal CD8+/CD57- T lymphocyte large granular lymphocyte (LGL) proliferation was observed in association with cytomegalovirus primary infection. Because the differential diagnosis of an increased number of LGLs includes both monoclonal LGL leukemia and polyclonal proliferation of LGL, patients in whom LGL proliferation is detected always need close hematological and clinical observation to determine whether therapeutic intervention is necessary.
我们报告了首例感染人类免疫缺陷病毒（HIV）的患者，该患者在巨细胞病毒初次感染时出现多克隆CD8⁺/CD57⁻T淋巴细胞大颗粒淋巴细胞（LGL）增殖。由于LGL数量增加的鉴别诊断包括单克隆LGL白血病和LGL的多克隆增殖，因此，检测到LGL增殖的患者始终需要密切的血液学和临床观察，以确定是否需要进行治疗干预。
