Watson S P, Asazuma N, Atkinson B, Berlanga O, Best D, Bobe R, Jarvis G, Marshall S, Snell D, Stafford M, Tulasne D, Wilde J, Wonerow P, Frampton J
Department of Pharmacology, University of Oxford, UK.
Thromb Haemost. 2001 Jul;86(1):276-88.
The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.
主要的激活诱导型胶原受体糖蛋白VI（GPVI）在过去两年内已被克隆。它是免疫球蛋白超家族蛋白的成员，与携带免疫受体酪氨酸激活基序（ITAM）的Fc受体γ链（FcRγ链）组成性结合。GPVI通过一条涉及Fc、B和T淋巴细胞受体所使用的几种蛋白质的信号通路进行信号传导，该信号通路发生在质膜中富含糖脂的膜结构域，即糖脂筏（GEMs）中。对GPVI的反应受血小板内皮细胞黏附分子-1（PECAM-1，CD31）以及可能其他携带免疫受体酪氨酸抑制基序（ITIM）的受体调控。尽管GPVI起着关键作用，但胶原信号事件与GPVI特异性配体之间存在重要差异。这可能反映了共受体在对胶原反应中的作用。
