Coughlin S R
Department of Medicine, University of California, San Francisco 94143-0130, USA.
Thromb Haemost. 2001 Jul;86(1):298-307.
G protein-coupled protease-activated receptors (PARs) provide one answer to the question of how coagulation factors and other proteases regulate cellular behaviors. In concert with the coagulation cascade, these receptors provide an elegant mechanism that links mechanical information in the form of tissue injury or vascular leak to cellular responses. Roles for PARs in hemostasis and thrombosis, inflammation, and perhaps even blood vessel development are beginning to emerge. Our current understanding of the role of PARs in platelet and endothelial cell activation and their potential importance in normal and disease states is discussed.
G蛋白偶联蛋白酶激活受体（PARs）为凝血因子和其他蛋白酶如何调节细胞行为这一问题提供了一种答案。与凝血级联反应协同作用，这些受体提供了一种精妙的机制，将组织损伤或血管渗漏形式的机械信息与细胞反应联系起来。PARs在止血、血栓形成、炎症乃至血管发育中的作用正逐渐显现。本文将讨论我们目前对PARs在血小板和内皮细胞激活中的作用及其在正常和疾病状态下潜在重要性的理解。
