Brady A G, Williams L E, Haught D, Abee C R
Department of Comparative Medicine, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Contemp Top Lab Anim Sci. 2000 Mar;39(2):27-9.
Dental calculus and associated periodontal disease are serious clinical problems in captive squirrel monkeys. Calculus begins to appear as early as 2 years of age, with subsequent development of periodontal disease, dental abscessation, tooth loss and other sequelae. When used as a feed additive, sodium hexametaphosphate (HMP) retards the growth of calculus on previously cleaned teeth in rhesus monkeys, lemurs, and other species. We wanted to determine whether HMP would reduce dental calculus in squirrel monkeys (Saimiri spp.) whose teeth had not been pre-cleaned. The study animals were divided into two groups. One received a standard diet; the other received an identical diet containing the HMP additive at a concentration effective in other primate and non-primate species that had received dental cleaning prior to treatment with HMP. Teeth were graded for extent of calculus formation at the start of the study and at 3 and 6 months during HMP treatment. We compared the results from the two groups both by total score per animal and according to tooth type (e.g., incisors versus incisors in test and control groups). At the end of 6 months, dental calculus did not differ significantly between the experimental groups. Therefore, we conclude that HMP is ineffective in squirrel monkeys with preexisting dental calculus.
牙结石及相关的牙周疾病是圈养松鼠猴面临的严重临床问题。牙结石早在2岁时就开始出现,随后会发展为牙周疾病、牙脓肿、牙齿脱落及其他后遗症。当用作饲料添加剂时,六偏磷酸钠(HMP)可延缓恒河猴、狐猴及其他物种在牙齿清洁后牙结石的生长。我们想确定HMP对牙齿未预先清洁的松鼠猴(松鼠属)是否能减少牙结石。研究动物被分为两组。一组接受标准饮食;另一组接受相同饮食,但含有在其他灵长类和非灵长类动物(在接受HMP治疗前已进行牙齿清洁)中有效的浓度的HMP添加剂。在研究开始时以及HMP治疗期间的3个月和6个月时,对牙齿的牙结石形成程度进行分级。我们通过每只动物的总分以及根据牙齿类型(例如,实验组和对照组的门齿对比)对两组结果进行比较。在6个月末,实验组之间的牙结石没有显著差异。因此,我们得出结论,HMP对已存在牙结石的松鼠猴无效。