Owiny J R, Strandberg J D
Johns Hopkins University, School of Medicine, 459 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA.
Contemp Top Lab Anim Sci. 2000 Nov;39(6):57-8.
Three 12- to 16-month-old female B6,129 apolipoprotein E-deficient mice were presented for necropsy because of bilateral masses in the gluteal region. Histopathologic examination revealed cholesterol granulomas extending from the superficial dermis to the underlying gluteal muscles. Microscopic granulomas were found on the face, perivaginal tissues, mesenteric lymph nodes, spleen, joints, kidneys, and choroid plexus. Other lesions included severe atherosclerosis of the aortic valves, aorta, pulmonary artery, and renal artery. Here we show that macroscopic cholesterol granulomas can develop in apolipoprotein E-deficient that receive a normal rodent diet.
三只12至16个月大的雌性B6,129载脂蛋白E缺陷小鼠因臀部区域出现双侧肿块而接受尸检。组织病理学检查显示胆固醇肉芽肿从浅表真皮延伸至下方的臀肌。在面部、阴道周围组织、肠系膜淋巴结、脾脏、关节、肾脏和脉络丛中发现了微观肉芽肿。其他病变包括主动脉瓣、主动脉、肺动脉和肾动脉的严重动脉粥样硬化。在此我们表明，接受正常啮齿动物饮食的载脂蛋白E缺陷小鼠可出现宏观胆固醇肉芽肿。
