Godbolt A M, Sullivan J J, Weedon D
Department of Dermatology, Royal Brisbane Hospital, Herston and Sullivan Nicolaides Pathology, Taringa, Queensland, Australia.
Australas J Dermatol. 2001 Aug;42(3):168-71. doi: 10.1046/j.1440-0960.2001.00508.x.
Keratoacanthoma is a unique clinicopathological entity, despite a recent trend to regard it as a variant of squamous cell carcinoma. The occurrence of perineural invasion is an uncommon phenomenon in keratoacanthomas, with a predilection for lesions on the face. We studied a series of 40 cases of keratoacanthoma in which perineural invasion occurred. Of the 40 cases, 27 were from the head or neck region. We found no metastasis or direct death attributable to the presence of perineural invasion in the 35 cases in our series for whom follow-up data were available. In only one case did local recurrence occur and this was not considered by the authors to be directly attributable to the presence of perineural invasion. These findings add further support to the notion that keratoacanthoma is biologically different from squamous cell carcinoma.
角化棘皮瘤是一种独特的临床病理实体，尽管最近有将其视为鳞状细胞癌变体的趋势。神经周围侵犯的发生在角化棘皮瘤中是一种不常见的现象，多见于面部病变。我们研究了一系列40例发生神经周围侵犯的角化棘皮瘤病例。在这40例病例中，27例来自头颈部区域。在我们系列中有随访数据的35例病例中，我们未发现因神经周围侵犯导致的转移或直接死亡。仅1例发生了局部复发，作者认为这并非直接归因于神经周围侵犯的存在。这些发现进一步支持了角化棘皮瘤在生物学上与鳞状细胞癌不同的观点。
