Goon A T, Tan S H
National Skin Centre, Singapore.
Australas J Dermatol. 2001 Aug;42(3):172-5. doi: 10.1046/j.1440-0960.2001.00509.x.
This is a retrospective study of all patients diagnosed to have pemphigus in our centre over a 3 year period. The case records of all patients with pemphigus from January 1995 to December 1997 were analysed. Fifty patients were diagnosed to have pemphigus during the study period. The diagnoses were pemphigus vulgaris in 31 patients, pemphigus foliaceus in 16, paraneoplastic pemphigus in two and IgA pemphigus in one. The average titre of anti-intercellular antibodies in patients with pemphigus vulgaris (1:96) was higher than the titre in patients with pemphigus foliaceus (1:69). The average initial dose of prednisolone required for disease control in patients with pemphigus vulgaris (62 mg/day) was significantly higher than that required for patients with pemphigus foliaceus (44 mg/day). In our study population, pemphigus vulgaris is a more severe and chronic disease than pemphigus foliaceus, as reflected in the higher titre of anti-intercellular antibodies, higher dose of systemic corticosteroids required for control of the disease, the longer duration to achieve complete remission and longer follow-up period.
这是一项对我院3年内确诊为天疱疮的所有患者进行的回顾性研究。分析了1995年1月至1997年12月期间所有天疱疮患者的病历。在研究期间，50例患者被诊断为天疱疮。其中寻常型天疱疮31例，落叶型天疱疮16例，副肿瘤性天疱疮2例，IgA天疱疮1例。寻常型天疱疮患者抗细胞间抗体的平均滴度（1:96）高于落叶型天疱疮患者（1:69）。寻常型天疱疮患者控制疾病所需的泼尼松龙平均初始剂量（62毫克/天）显著高于落叶型天疱疮患者（44毫克/天）。在我们的研究人群中，寻常型天疱疮是一种比落叶型天疱疮更严重、更慢性的疾病，这体现在抗细胞间抗体滴度更高、控制疾病所需的全身皮质类固醇剂量更高、实现完全缓解所需的时间更长以及随访期更长。
