Kimble J E, Mollagård K
Cell Tissue Res. 1975 Jun 9;159(2):195-204. doi: 10.1007/BF00219155.
Neurons which initially lie in the basal region of the subcommissural organ (SCO) were investigated in 20 rabbit fetuses from day 15 to 30 of gestation, and in eight neonatal, 4 and 8 day old rabbits. These SCO-associated neurons, first observed on day 17 of gestation, develop into (1) a rostral mesodiencephalic nerve cell group situated in an area dorsal to the rostral-most part of the SCO and (2) a more caudal layer of single neurons extending throughout the length of the SCO. The present findings are discussed in relation to recent histochemical studies that demonstrated AChE-positive neurons in the pineal complex and subcommissural area of frogs and to recent fluorescence microscopic studies in fetal and adult rats in which a 5-HT system is known to extend from the nucleus raphe dorsalis (B7) along the SCO to the pineal stalk and habenular region. The term "SCO-associated neurons" is a purely morphological way of describing the neurons in question as the neural interconnections of these neurons are still a matter of speculation.
在妊娠第15天至30天的20只兔胎儿以及8只新生兔（4日龄和8日龄）中，对最初位于连合下器官（SCO）基部区域的神经元进行了研究。这些与SCO相关的神经元在妊娠第17天首次被观察到，发育为：（1）位于SCO最前端背侧区域的嘴侧中脑间脑神经细胞群；（2）贯穿SCO全长的更靠尾侧的单层神经元。结合最近的组织化学研究（该研究证明青蛙松果体复合体和连合下区域存在乙酰胆碱酯酶阳性神经元）以及最近对胎儿和成年大鼠的荧光显微镜研究（已知5-羟色胺系统从背侧中缝核（B7）沿着SCO延伸至松果体柄和缰核区域）对本研究结果进行了讨论。术语“与SCO相关的神经元”是描述相关神经元的一种纯粹形态学方式，因为这些神经元的神经互连仍有待推测。
