Yeo S W, Park S N, Park Y S, Suh B D, Han H, Choi H B, Kim T G
Department of Otolaryngology, College of Medicine, The Catholic University of Korea, Seoul 137-040, Korea.
Arch Otolaryngol Head Neck Surg. 2001 Aug;127(8):945-9. doi: 10.1001/archotol.127.8.945.
To investigate the association of HLA class II alleles with the susceptibility to sudden sensorineural hearing loss and with the results of corticosteroid treatment in the Korean population.
HLA-DRB1, -DQA1, -DQB1, and -DPB1 genotyping by the sequence-specific oligonucleotide probes method in 41 patients with sudden sensorineural hearing loss and in 206 healthy control subjects. Initial hearing levels at the onset of hearing loss and final hearing levels after treatment were evaluated for the association with HLA class II alleles.
Tertiary care referral center, ambulatory and hospitalized care.
Forty-one patients (24 men and 17 women; mean age, 49.2 years) were compared with 206 controls. Patients were divided into 2 groups according to their response to corticosteroid therapy (good response vs nonresponse).
The frequencies of HLA-DRB1, -DQA1, -DQB1, and -DPB1 alleles were not significantly different between patients and controls (P>.05). When an association between the results of corticosteroid treatment and the frequency of HLA alleles was evaluated, the frequencies of HLA-DRB114 (relative risk [RR] = 3.5, P<.02), -DQA103 (RR = 4.2, P<.02), and -DQA105 (RR = 3.1, P<.03) were significantly increased, but HLA-DQA101 (RR = 0.2, P<.004) and -DQB106 (RR = 0.2, P<.009) were decreased in the group nonresponsive to corticosteroid therapy, compared with the controls. The distribution of HLA-DQA101 (P<.04), -DQB106 (P<.02), and -DQA103 (P<.003) was significantly different between the responsive and the nonresponsive groups. HLA-DQA1 allelic combination analysis showed that the frequencies of DQA1*03 and *05 had a high RR value in patients with sudden sensorineural hearing loss (RR = 4.1, P<.003) and in patients in the nonresponsive group (RR = 8.9, P<.001), compared with the controls.
The presence of HLA class II alleles may be a useful genetic marker in forecasting a prognosis in Korean patients with sudden sensorineural hearing loss.
研究韩国人群中人类白细胞抗原（HLA）Ⅱ类等位基因与突发性感音神经性听力损失易感性以及皮质类固醇治疗结果之间的关联。
采用序列特异性寡核苷酸探针法对41例突发性感音神经性听力损失患者和206例健康对照者进行HLA-DRB1、-DQA1、-DQB1和-DPB1基因分型。评估听力损失发作时的初始听力水平和治疗后的最终听力水平与HLAⅡ类等位基因的关联。
三级医疗转诊中心，门诊和住院治疗。
41例患者（24例男性和17例女性；平均年龄49.2岁）与206例对照者进行比较。根据患者对皮质类固醇治疗的反应将其分为两组（良好反应组与无反应组）。
患者与对照者之间HLA-DRB1、-DQA1、-DQB1和-DPB1等位基因频率无显著差异（P>0.05）。在评估皮质类固醇治疗结果与HLA等位基因频率之间的关联时，与对照者相比，无反应组中HLA-DRB114（相对危险度[RR]=3.5，P<0.02）、-DQA103（RR=4.2，P<0.02）和-DQA105（RR=3.1，P<0.03）的频率显著增加，但HLA-DQA101（RR=0.2，P<0.004）和-DQB106（RR=0.2，P<0.009）的频率降低。反应组与无反应组之间HLA-DQA101（P<0.04）、-DQB106（P<0.02）和-DQA103（P<0.003）的分布存在显著差异。HLA-DQA1等位基因组合分析显示，与对照者相比，突发性感音神经性听力损失患者（RR=4.1，P<0.003）和无反应组患者（RR=8.9，P<0.001）中DQA103和05的频率具有较高的RR值。
HLAⅡ类等位基因的存在可能是预测韩国突发性感音神经性听力损失患者预后的有用遗传标志物。
