Goodman M J, Chung C S
Clin Genet. 1975 Jul;8(1):66-74. doi: 10.1111/j.1399-0004.1975.tb01956.x.
Family data from 6,559 diabetic propositi were analyzed using the method of complex segregation analysis in an attempt to discriminate the two models of two-allele single-locus inheritance and multifactorial inheritance for early, middle, and late onset diabetes. The three parameters in the single locus model were: degree of dominance, penetrance, and proportion of phenocopies. In early onset diabetes, the heritability estimated from the multifactorial model was so high as to inidcate major gene action. In middle and late onset diabetes, best fitting single-locus models were found to explain the data as well as the multifactorial model.
对6559名糖尿病先证者的家族数据进行了分析，采用复杂分离分析方法，试图区分早发、中年发和晚发糖尿病的双等位基因单基因座遗传和多因素遗传这两种模式。单基因座模型中的三个参数为：显性程度、外显率和拟表型比例。在早发糖尿病中，从多因素模型估计的遗传度高到表明存在主基因作用。在中年发和晚发糖尿病中，发现最佳拟合的单基因座模型能够像多因素模型一样解释数据。
