罗库溴铵用于小儿急诊科控制插管并使用肌肉松弛剂的安全性和有效性。
Safety and efficacy of rocuronium for controlled intubation with paralytics in the pediatric emergency department.
作者信息
Mendez D R, Goto C S, Abramo T J, Wiebe R A
机构信息
Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
出版信息
Pediatr Emerg Care. 2001 Aug;17(4):233-6. doi: 10.1097/00006565-200108000-00001.
BACKGROUND
Controlled intubation in the pediatric emergency department (ED) requires a paralytic agent that is safe, efficacious, and of rapid onset. The safety of succinylcholine has been challenged, leading some clinicians to use vecuronium as an alternative. Rocuronium's onset is similar to that of succinylcholine.
OBJECTIVE
To evaluate the safety and efficacy of rocuronium for controlled intubation with paralysis (CIP) in the pediatric ED.
METHODS
A retrospective, observational study reviewed the records of patients less than 15 years of age, who received controlled intubation with paralytics at two Dallas EDs. The patients received either vecuronium or rocuronium.
RESULTS
The study included 84 patients (vecuronium 19, rocuronium 65). Complications were similar between the two groups. Rocuronium had a shorter time from administration to intubation when compared to vecuronium (P < 0.05).
CONCLUSION
Rocuronium is as safe and efficacious as vecuronium for CIP in the pediatric ED.
背景
儿科急诊科的控制性插管需要一种安全、有效且起效迅速的麻痹剂。琥珀酰胆碱的安全性受到了质疑，这使得一些临床医生使用维库溴铵作为替代药物。罗库溴铵的起效时间与琥珀酰胆碱相似。
目的
评估罗库溴铵用于儿科急诊科控制性麻痹插管（CIP）的安全性和有效性。
方法
一项回顾性观察性研究回顾了在达拉斯两家急诊科接受麻痹剂控制性插管的15岁以下患者的记录。患者接受维库溴铵或罗库溴铵治疗。
结果
该研究纳入了84例患者（维库溴铵组19例，罗库溴铵组65例）。两组的并发症相似。与维库溴铵相比，罗库溴铵从给药到插管的时间更短（P < 0.05）。
结论
在儿科急诊科，罗库溴铵用于CIP与维库溴铵一样安全有效。
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