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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Clin Sci Mol Med. 1975 Jul;49(1):73-6. doi: 10.1042/cs0490073.

The effect of antidiuretic hormone (ADH) on isoprenaline-stimulated renin secretion was examined in the isolated rat kidney perfused with modified Krebs-Ringer saline. 2. Intrarenal infusion OF ADH effectively prevented stimulation of renin secretion by isoprenaline whilst increasing renal perfusion pressure. 3. The exclusion of calcium ions from the perfusion medium abolished the vasoconstrictor effect of ADH and attenuated the inhibitory effect of ADH on isoprenaline-stimulated renin secretion. However, significant suppression of renin secretion was still apparent compared with experiments where isoprenaline was infused alone. 4. These observations indicate that ADH inhibits renin secretion and that this is effected by a direct action on the kidney. Although this may be partly mediated by the rise in renal perfusion pressure, an additional direct effect of ADH on the renin-producing cell, which is dependent on the availability of calcium ions, is proposed.

在灌注改良克氏-林格氏生理盐水的离体大鼠肾脏中，研究了抗利尿激素（ADH）对异丙肾上腺素刺激的肾素分泌的影响。2. 肾内输注ADH在增加肾灌注压的同时，有效地抑制了异丙肾上腺素对肾素分泌的刺激。3. 灌注液中去除钙离子消除了ADH的血管收缩作用，并减弱了ADH对异丙肾上腺素刺激的肾素分泌的抑制作用。然而，与单独输注异丙肾上腺素的实验相比，肾素分泌仍有明显的抑制。4. 这些观察结果表明，ADH抑制肾素分泌，且这是通过对肾脏的直接作用实现的。虽然这可能部分由肾灌注压升高介导，但推测ADH对产肾素细胞还有额外的直接作用，且该作用依赖于钙离子的存在。

Clin Sci Mol Med. 1975 Jul;49(1):73-6. doi: 10.1042/cs0490073.

The effect of antidiuretic hormone (ADH) on isoprenaline-stimulated renin secretion was examined in the isolated rat kidney perfused with modified Krebs-Ringer saline. 2. Intrarenal infusion OF ADH effectively prevented stimulation of renin secretion by isoprenaline whilst increasing renal perfusion pressure. 3. The exclusion of calcium ions from the perfusion medium abolished the vasoconstrictor effect of ADH and attenuated the inhibitory effect of ADH on isoprenaline-stimulated renin secretion. However, significant suppression of renin secretion was still apparent compared with experiments where isoprenaline was infused alone. 4. These observations indicate that ADH inhibits renin secretion and that this is effected by a direct action on the kidney. Although this may be partly mediated by the rise in renal perfusion pressure, an additional direct effect of ADH on the renin-producing cell, which is dependent on the availability of calcium ions, is proposed.

在灌注改良克氏-林格氏生理盐水的离体大鼠肾脏中，研究了抗利尿激素（ADH）对异丙肾上腺素刺激的肾素分泌的影响。2. 肾内输注ADH在增加肾灌注压的同时，有效地抑制了异丙肾上腺素对肾素分泌的刺激。3. 灌注液中去除钙离子消除了ADH的血管收缩作用，并减弱了ADH对异丙肾上腺素刺激的肾素分泌的抑制作用。然而，与单独输注异丙肾上腺素的实验相比，肾素分泌仍有明显的抑制。4. 这些观察结果表明，ADH抑制肾素分泌，且这是通过对肾脏的直接作用实现的。虽然这可能部分由肾灌注压升高介导，但推测ADH对产肾素细胞还有额外的直接作用，且该作用依赖于钙离子的存在。