Li Q, Qi B, Oka K, Shimakage M, Yoshioka N, Inoue H, Hakura A, Kodama K, Stanbridge E J, Yutsudo M
Department of Tumor Virology, Research Institute for Microbial Diseases, Osaka University, Suita 565-0871, Japan.
Oncogene. 2001 Jul 5;20(30):3929-36. doi: 10.1038/sj.onc.1204536.
Although apoptosis plays an essential role in the embryogenesis and homeostasis of multicellular organisms, this mechanism has not yet been fully clarified. We isolated a novel human apoptosis-inducing gene, ASY, which encodes an endoplasmic reticulum-targeting protein without any known apoptosis-related motifs. This gene is identical to the Nogo-B, a splice variant of the Nogo-A which has recently been shown to be an inhibitor of neuronal regeneration in the central nervous system. Ectopic expression of the ASY gene led to extensive apoptosis, particularly in cancer cells. Furthermore, transcription of the ASY gene was suppressed in small cell lung cancer. These results suggest that a new type of apoptosis-inducing gene, namely, ASY, may be involved in the development of certain types of cancer.
尽管细胞凋亡在多细胞生物的胚胎发育和体内平衡中起着至关重要的作用，但这一机制尚未完全阐明。我们分离出了一种新的人类细胞凋亡诱导基因ASY，它编码一种靶向内质网的蛋白质，且没有任何已知的与细胞凋亡相关的基序。该基因与Nogo-B相同，Nogo-B是Nogo-A的一个剪接变体，最近已被证明是中枢神经系统中神经元再生的抑制剂。ASY基因的异位表达导致广泛的细胞凋亡，尤其是在癌细胞中。此外，ASY基因的转录在小细胞肺癌中受到抑制。这些结果表明，一种新型的细胞凋亡诱导基因，即ASY，可能参与了某些类型癌症的发生发展。
