Jacobs C, Bertino J R, Goffinet D R, Fee W E, Goode R L
Otolaryngology. 1978 Sep-Oct;86(5):ORL-780-3. doi: 10.1177/019459987808600523.
Sixteen patients with advanced head and neck carcinomas were treated with cis-diaminedichloro platinum chemotherapy; seven preoperatively and nine for recurrent disease. Cis-platinum was given by 24-hour infusions of 80 mg/m2 every three weeks. There was 50% regression in 38% (6) of the patients; another 38% (6) had 25% to 50% regression. Toxicity was minimal, with vomiting occurring in 75% (12) of the courses, renal toxicity in 6% (2), leukopenia in 13% (4), thrombocytopenia in 9% (3), and anemia in 31% (10). Of the seven patients who had serial audiograms, only one experienced ototoxicity. Cis-platinum, given by 24-hour infusion, was effective in reducing tumor bulk in 75% (12) of the patients, with advanced head and neck carcinomas, without undue morbidity.
16例晚期头颈癌患者接受了顺二氯二氨铂化疗；7例在术前接受治疗，9例用于复发性疾病的治疗。顺铂每三周通过24小时输注给予80mg/m²。38%（6例）的患者肿瘤缩小了50%；另有38%（6例）的患者肿瘤缩小了25%至50%。毒性极小，75%（12个疗程）出现呕吐，6%（2例）出现肾毒性，13%（4例）出现白细胞减少，9%（3例）出现血小板减少，31%（10例）出现贫血。在7例接受系列听力图检查的患者中，只有1例出现耳毒性。通过24小时输注给予顺铂对75%（12例）的晚期头颈癌患者有效，可减少肿瘤体积，且无过度发病率。
