Lin Y L, Huang J L, Chen L C, Wang C R
Department of Pediatrics, Chang Gung Children's Hospital and Chang Gung University, Taoyuan, Taiwan.
Asian Pac J Allergy Immunol. 2001 Mar;19(1):1-6.
Chronic sinusitis is frequently associated with allergy and asthma. Previous studies have shown that serum immunoglobulin E (IgE) levels correlate with allergy and asthma in adults. Because the role of allergic inflammation in the severity of chronic sinusitis remains controversial in children, we set out to determine whether a correlation exists between serum levels of total and specific IgE and the severity of chronic sinusitis in children. Forty-four children with chronic sinusitis were enrolled in the study. Computed tomographic scans were reviewed and scored for the severity of sinusitis. All children were mite-sensitive. Serum samples were assayed for total IgE and specific IgE antibodies to mite allergen using a fluoroimmunoassay. Fourteen subjects had extensive sinus disease. There was no significant difference in the average of total and specific IgE between the subjects with extensive and limited disease (p = 0.562 and 0.755, respectively). Thirty-four subjects were diagnosed with asthma. The subjects with extensive sinus disease had a higher prevalence of moderate to severe asthma than the subjects with limited disease (p = 0.006), but there was no significant difference in the average of total and specific IgE between the subjects with different severities of asthma. (p = 0.833 and 0.425, respectively). The data suggests that levels of total or specific IgE do not correlate with severity of chronic sinusitis in children. Nonetheless, the severity of chronic sinusitis and asthma correlate well with each other irrespective of total and specific IgE.
慢性鼻窦炎常与过敏及哮喘相关。既往研究表明，血清免疫球蛋白E（IgE）水平与成人的过敏及哮喘相关。由于变应性炎症在儿童慢性鼻窦炎严重程度中的作用仍存在争议，我们着手确定血清总IgE及特异性IgE水平与儿童慢性鼻窦炎严重程度之间是否存在相关性。44例慢性鼻窦炎患儿纳入本研究。对计算机断层扫描结果进行复查，并对鼻窦炎严重程度进行评分。所有儿童均对螨敏感。采用荧光免疫测定法检测血清样本中的总IgE及针对螨过敏原的特异性IgE抗体。14例受试者患有广泛的鼻窦疾病。广泛病变组与局限性病变组的总IgE及特异性IgE平均值无显著差异（分别为p = 0.562和0.755）。34例受试者被诊断为哮喘。广泛鼻窦疾病组中重度哮喘的患病率高于局限性病变组（p = 0.006），但不同哮喘严重程度组的总IgE及特异性IgE平均值无显著差异（分别为p = 0.833和0.425）。数据表明，总IgE或特异性IgE水平与儿童慢性鼻窦炎的严重程度无关。尽管如此，无论总IgE及特异性IgE如何，慢性鼻窦炎和哮喘的严重程度之间存在良好的相关性。
