Ruegsegger M A, Marchant R E
Department of Biomedical Engineering, Wickenden Building 202, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-7207, USA.
J Biomed Mater Res. 2001 Aug;56(2):159-167. doi: 10.1002/1097-4636(200108)56:2<159::aid-jbm1080>3.0.co;2-r.
A series of oligomaltose surfactant polymers were prepared by the simultaneous coupling of hydrophilic maltolactone [of 2(M2), 7(M7), or 15(M15) glucose units] and hydrophobic N-(hexanoyloxy)succinimide (Hex) groups to the amino groups of a poly(vinyl amine) backbone. The surfactants were characterized by FTIR and 1H-NMR spectroscopies for purity and composition. Contact-angle and AFM measurements confirmed full monolayer adsorption for all surfactants on a model surface, highly oriented pyrolitic graphite, while full coverage was observed on polyethylene only for PVAm (M7:Hex) due to the optimal M7:Hex ratio and Hex chain density. On graphite, protein resistance increased with increasing coating thickness from 81.4 to 85.8 to 95.8% for the M2, M7, and M15 surfactants, respectively. Additionally, static platelet adhesion on all three surfactants dropped substantially to 15% (M2), 17% (M7), and 16% (M15)compared to glass (adhesion normalized to 100%) and a polyurethane (24%) surface. Protein- and platelet-resistant properties of the controlled oligomaltose layers are discussed by analysis of molecular modeling, oligomaltose and hexanoyl chain densities, and surfactant stability.
通过将亲水性麦芽内酯[含2个（M2）、7个（M7）或15个（M15）葡萄糖单元]和疏水性N-（己酰氧基）琥珀酰亚胺（Hex）基团同时偶联到聚乙烯胺主链的氨基上，制备了一系列低聚麦芽糖表面活性剂聚合物。通过傅里叶变换红外光谱（FTIR）和核磁共振氢谱（1H-NMR）对表面活性剂的纯度和组成进行了表征。接触角和原子力显微镜测量证实，所有表面活性剂在模型表面——高度取向的热解石墨上均能形成完整的单分子层吸附，而由于最佳的M7:Hex比例和Hex链密度，仅在聚乙烯上观察到PVAm（M7:Hex）形成了完全覆盖。在石墨上，M2、M7和M15表面活性剂的抗蛋白质能力随涂层厚度增加而增强，分别从81.4%提高到85.8%再到95.8%。此外，与玻璃（粘附率归一化为100%）和聚氨酯（24%）表面相比，所有三种表面活性剂上的静态血小板粘附率大幅下降至15%（M2）、17%（M7）和16%（M15）。通过分子建模、低聚麦芽糖和己酰链密度以及表面活性剂稳定性分析，讨论了可控低聚麦芽糖层的抗蛋白质和抗血小板性能。
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