Vána S, Nĕmec J
Endokrinologie. 1975 Jan;64(2):243-8.
In rapidly changing thyroid state Rodbard's Q-Kd interval (reflecting heart contractility) changes more rapidly, than ART (reflecting skeletal muscle contractility). After withdrawal of substitutive therapy in athyreotic patients the Q-Kd intervals prolongs more rapidly than ART and during intensive treatment of hypothyroidism the Q-Kd interval shortens more rapidly that ART. A more rapid metabolic turnover in heart muscle in comparison with skeletal muscle is proposed as suitable explanation. Practical consequences for early diagnosis of hypothyroidism and for instant functional diagnosis of thyroidal disorders are stressed.
在甲状腺状态快速变化时，罗德巴德的Q-Kd间期（反映心脏收缩力）比ART（反映骨骼肌收缩力）变化更快。甲状腺功能减退患者停用替代治疗后，Q-Kd间期比ART延长得更快，而在甲状腺功能减退症的强化治疗期间，Q-Kd间期比ART缩短得更快。有人提出，与骨骼肌相比，心肌代谢转换更快是合适的解释。强调了对甲状腺功能减退症早期诊断和甲状腺疾病即时功能诊断的实际意义。
