[拉氧头孢钠的极谱行为及其痕量测定]

[Polarographic behavior of latamoxef sodium and its trace determination].

作者信息

Gu H Y, Sun D M, Yu A M, Chen H Y

机构信息

Department of Chemistry, Nanjing University, Nanjing 210093.

出版信息

Yao Xue Xue Bao. 1997 May;32(5):373-6.

PMID:11498875

Abstract

In the medium of HCl-KCl (pH 1-2) by means of cyclic voltammetry and differential pulse polarography (DPP), the mechanism of the electrode reaction for latamoxef sodium (Shiomarin) at static mercury drop electrode (SMDE) and hanging mercury drop electrode (HMDE) has been proposed. A sensitive method for the determination of nanomolar concentration of latamoxef sodium by DPP was developed. The peak potential was -0.62 V (vs Ag/AgCl). The linear range was from 1 x 10(-8) to 8 x 10(-4) mol.L-1, the detection limit was ca. 4 x 10(-9) mol.L-1(tac = 90 s). The method was applied to the determination of latamoxef sodium in injection with satisfactory results. The possibility for the direct determination of latamoxef sodium in mimic urine sample was also studied.

摘要

在HCl-KCl（pH 1 - 2）介质中，通过循环伏安法和差分脉冲极谱法（DPP），提出了拉氧头孢钠（噻吗灵）在静态汞滴电极（SMDE）和悬汞滴电极（HMDE）上的电极反应机理。开发了一种用DPP测定纳摩尔浓度拉氧头孢钠的灵敏方法。峰电位为 - 0.62 V（相对于Ag/AgCl）。线性范围为1×10⁻⁸至8×10⁻⁴ mol·L⁻¹，检测限约为4×10⁻⁹ mol·L⁻¹（tac = 90 s）。该方法用于注射液中拉氧头孢钠的测定，结果令人满意。还研究了直接测定模拟尿液样品中拉氧头孢钠的可能性。