[Studies on electrochemical behaviour of antiepilepsirine and its adsorptive voltammetry].

Antiepilepsirine is a kind of new antiepileptic drug. In this paper, a new method, adsorptive voltammetry (ADV) has been established for the determination of antiepilepsirine. In 0.20 mol/L H2SO4 solution, a sensitive reduction wave of antiepilepsirine was obtained by ADV after preconcentration on the surface of hanging mercury drop electrode (HMDE) (Ei = 0.7V, v = 100 mV/s), the peak potential was -0.94V (vs Ag/AgCl). The linear range between the peak current and the concentration of antiepilepsirine was 3.0 x 10(-9)-3.0 x 10(-6) mol/L with a detection limit of 1.0 x 10(-9) mol/L. Antiepilepsirine in tablet and urine samples was determined by using this method. The electrochemical behaviour of the system and its electrode reaction mechanism were studied by means of linear sweep and cyclic voltammetry, constant potential coulometry, normal pulse polarography (NPP), etc. The diffusion coefficient D was 7.7 x 10(-6) cm2/s. The electrode reaction rate constant was 1.5 x 10(-3) cm/s. The number of reduction electron n was 2. The electron transfer coefficient was 0.52. The electrode reduction process was shown to be irreversible with the adsorptive characteristics.