Liu X Y, Li Q L
Department of Chemistry, Beijing Normal University.
Yao Xue Xue Bao. 1993;28(3):222-8.
Antiepilepsirine is a kind of new antiepileptic drug. In this paper, a new method, adsorptive voltammetry (ADV) has been established for the determination of antiepilepsirine. In 0.20 mol/L H2SO4 solution, a sensitive reduction wave of antiepilepsirine was obtained by ADV after preconcentration on the surface of hanging mercury drop electrode (HMDE) (Ei = 0.7V, v = 100 mV/s), the peak potential was -0.94V (vs Ag/AgCl). The linear range between the peak current and the concentration of antiepilepsirine was 3.0 x 10(-9)-3.0 x 10(-6) mol/L with a detection limit of 1.0 x 10(-9) mol/L. Antiepilepsirine in tablet and urine samples was determined by using this method. The electrochemical behaviour of the system and its electrode reaction mechanism were studied by means of linear sweep and cyclic voltammetry, constant potential coulometry, normal pulse polarography (NPP), etc. The diffusion coefficient D was 7.7 x 10(-6) cm2/s. The electrode reaction rate constant was 1.5 x 10(-3) cm/s. The number of reduction electron n was 2. The electron transfer coefficient was 0.52. The electrode reduction process was shown to be irreversible with the adsorptive characteristics.
抗癫痫灵是一种新型抗癫痫药物。本文建立了一种吸附伏安法（ADV）测定抗癫痫灵的新方法。在0.20 mol/L硫酸溶液中，抗癫痫灵在悬汞滴电极（HMDE）表面预富集后，通过吸附伏安法获得灵敏的还原波（Ei = 0.7V，v = 100 mV/s），峰电位为-0.94V（vs Ag/AgCl）。抗癫痫灵的峰电流与浓度在3.0×10⁻⁹ - 3.0×10⁻⁶ mol/L范围内呈线性关系，检出限为1.0×10⁻⁹ mol/L。采用该方法测定了片剂和尿液样品中的抗癫痫灵。通过线性扫描伏安法、循环伏安法、恒电位库仑法、常规脉冲极谱法（NPP）等研究了该体系的电化学行为及其电极反应机理。扩散系数D为7.7×10⁻⁶ cm²/s。电极反应速率常数为1.5×10⁻³ cm/s。还原电子数n为2。电子转移系数为0.52。电极还原过程表现为具有吸附特性的不可逆过程。
