Kavic S, Cohen M A, Sauer M V, Lindheim S R
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons, New York, New York, USA.
J Reprod Med. 2001 Jul;46(7):637-40.
To assess the predictive value of measuring serum day 5 E2 and in vitro fertilization (IVF) cycle outcome of oocyte donors undergoing controlled ovarian hyperstimulation (COH).
Retrospective data analysis.
Day 5 E2 significantly correlated with the peak serum E2 and number of retrieved mature oocytes. The pregnancy rates associated with stimulated day 5 E2 > 70 pg/mL were significantly greater than in cycles with levels < 70 pg/mL (58%, 71/123, versus 25%, 15/60; P < .05).
The cycle performance of an oocyte donor can be predicted by measuring cycle day 5 serum E2 during COH. Poor-prognosis cycles can be identified and discontinued, saving patients and the program unnecessary exspense.
评估在接受控制性卵巢刺激（COH）的卵母细胞捐赠者中，测量第5天血清雌二醇（E2）对体外受精（IVF）周期结局的预测价值。
回顾性数据分析。
第5天E2与血清E2峰值及回收的成熟卵母细胞数量显著相关。刺激周期第5天E2>70 pg/mL时的妊娠率显著高于E2水平<70 pg/mL的周期（58%，71/123，对比25%，15/60；P<.05）。
通过在COH期间测量周期第5天血清E2，可以预测卵母细胞捐赠者的周期表现。可以识别并终止预后不良的周期，为患者和项目节省不必要的费用。
