[白细胞介素-1对瘢痕来源成纤维细胞胶原蛋白合成的影响]
[The effects of IL-1 on synthesis of collagen in scar-derived fibroblasts].
作者信息
Yang D, Luo J, Zhu J
机构信息
Department of Plastic Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515.
出版信息
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1999 Nov;15(6):434-6.
OBJECTIVE
To investigate modulation of cytokines on biological activities of scar-derived fibroblasts.
METHODS
This study focused on the effects of interleukin-1 (IL-1) on collagen biosynthesis, nucleic acid, and cell organs of fibroblasts.
RESULTS
The results showed the IL-1 could reduce not only the collagen synthesis of fibroblasts, but also quantity of nucleic acid.
CONCLUSION
The authors confirm that IL-1 is a cytokine with down-regulation effect on scar formation, and suggest that IL-1 can play an important role in prevention and treatment of scar.
目的
研究细胞因子对瘢痕来源成纤维细胞生物学活性的调节作用。
方法
本研究聚焦于白细胞介素-1（IL-1）对成纤维细胞胶原蛋白生物合成、核酸及细胞器官的影响。
结果
结果显示IL-1不仅可降低成纤维细胞的胶原蛋白合成，还可减少核酸数量。
结论
作者证实IL-1是一种对瘢痕形成具有下调作用的细胞因子，并表明IL-1在瘢痕的防治中可发挥重要作用。
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