Rochling F A
Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA.
Clin Cornerstone. 2001;3(6):1-12. doi: 10.1016/s1098-3597(01)90074-2.
Serum liver tests are important but often problematic in evaluating patients with and without symptoms of hepatic disease. The common term "liver function tests" is misleading because most tests used in clinical practice measure hepatocellular damage not function. True liver function tests are those that measure synthesis of proteins made by the liver (albumin, clotting factors) or the liver's capacity to metabolize drugs. A commonly ordered panel of automated tests includes bilirubin, aminotransferases, alkaline phosphatase, and gamma-glutamyl transpeptidase. This article reviews patterns of elevated enzyme values encountered in liver diseases and their diagnostic limitations and provides an algorithm for evaluating abnormal liver test results.
血清肝功能检查在评估有无肝病症状的患者时很重要，但往往存在问题。常用的“肝功能检查”一词具有误导性，因为临床实践中使用的大多数检查测量的是肝细胞损伤而非功能。真正的肝功能检查是那些测量肝脏合成的蛋白质（白蛋白、凝血因子）或肝脏代谢药物能力的检查。一组常见的自动化检查项目包括胆红素、转氨酶、碱性磷酸酶和γ-谷氨酰转肽酶。本文回顾了肝病中酶值升高的模式及其诊断局限性，并提供了一种评估异常肝功能检查结果的算法。
