Beumer J H, Bosman I J, Maes R A
Department of Biomedical Analysis, Faculty of Pharmacy, University of Utrecht, The Netherlands.
Int J Clin Pract. 2001 Jul-Aug;55(6):353-7.
To study the potential of hair as a biological specimen in therapeutic drug monitoring (TDM), a review of the correlation between hair concentration, blood levels, dose and therapeutic effects of various drugs is presented. The results indicate there is a fair correlation between plasma and hair for several medicines. Moreover, hair samples have the advantage of providing information of more prolonged drug intake, thus allowing a better evaluation of patient compliance. Using segmental hair analysis, only a single sample is necessary. We conclude that hair has potential as a biological specimen in TDM--at least as far as compliance is concerned and possibly as a longer term record of drug concentrations--and that correlation between hair concentration, blood levels and clinical efficacy should be investigated for all drugs where TDM is indicated.
为研究头发作为治疗药物监测（TDM）生物样本的潜力，本文综述了各种药物的头发浓度、血药浓度、剂量与治疗效果之间的相关性。结果表明，几种药物的血浆浓度与头发浓度之间存在一定相关性。此外，头发样本具有提供更长时间药物摄入信息的优势，从而能更好地评估患者的依从性。采用分段头发分析，只需一个样本即可。我们得出结论，头发有潜力作为TDM的生物样本——至少就依从性而言，可能还能作为药物浓度的长期记录——对于所有需要进行TDM的药物，都应研究头发浓度、血药浓度与临床疗效之间的相关性。
