Michel J B, Plissonnier D, Gomes D
Unité 460 de 1'INSERM, CHU X. Bichat, 16 rue Henri Huchard-75018 Paris.
Bull Acad Natl Med. 2001;185(3):605-12; discussion 612-3.
Contrasting with acute rejection, chronic rejection of arterial allograft don't involve leukocyte passengers from the graft to the host. Chronic rejection involves the proteins of the major histocompatibility complexes. Experimental studies in rats showed that the process evolved in three stages: a first stage of histo-incompatibility recognition mediated by the graft endothelium, a second stage of immune antibody-dependent injury of allogenic smooth muscle cells of the media associated with inflammatory infiltration of the adventitia, lastly a third stage of scarring process including intimal proliferation and adventitial fibrosis.
与急性排斥反应不同，动脉同种异体移植物的慢性排斥反应不涉及白细胞从移植物进入宿主。慢性排斥反应涉及主要组织相容性复合体的蛋白质。在大鼠身上进行的实验研究表明，这个过程分为三个阶段：第一阶段是由移植物内皮介导的组织不相容性识别，第二阶段是免疫抗体依赖性的中膜同种异体平滑肌细胞损伤，伴有外膜的炎症浸润，最后是第三阶段的瘢痕形成过程，包括内膜增生和外膜纤维化。
