Brasch J, Henseler T, Aberer W, Fuchs T, Hoeck U, Kreilgård B
Department of Dermatology, University of Kiel, Germany.
Acta Derm Venereol. 2001 May;81(2):122-4. doi: 10.1080/00015550152384263.
There is still some doubt about the reproducibility of patch tests. A sound assessment needs optimized and unbiased studies. This study analysed the results of a double-blind multicentre study with nickel sulfate and potassium dichromate patch tests attached synchronously to both sides of the back of patients with a history of nickel allergy, conducted with a highly standardized randomized test system (TRUE-test). Out of 589 patients tested, a total of 388 had responded with allergic reactions to nickel sulfate and 130 to potassium dichromate. The reproducibility of positive nickel (dichromate) patch tests was 99.2% (90.8%). The reaction index was also calculated, which relates the number of allergic reactions obtained with a test preparation to the number of questionable and irritant reactions; the reaction index can range from -1 (questionable and irritant reactions only occur) to 1 (allergic reactions only occur). For nickel sulfate the reaction index was 0.91, but it was only 0.23 for potassium dichromate, as a result of considerably more questionable reactions. In conclusion, a highly synchronous reproducibility of results can be achieved by using a well-standardized patch-test system, especially with nickel sulfate. However, distinct allergens and test systems need to be evaluated separately.
斑贴试验的可重复性仍存在一些疑问。可靠的评估需要优化且无偏倚的研究。本研究分析了一项双盲多中心研究的结果，该研究使用高度标准化的随机测试系统（TRUE-测试），将硫酸镍和重铬酸钾斑贴试验同步贴于有镍过敏史患者的背部两侧。在589名接受测试的患者中，共有388人对硫酸镍有过敏反应，130人对重铬酸钾有过敏反应。阳性镍（重铬酸盐）斑贴试验的可重复性为99.2%（90.8%）。还计算了反应指数，该指数将测试制剂获得的过敏反应数量与可疑和刺激性反应数量相关联；反应指数范围从-1（仅出现可疑和刺激性反应）到1（仅出现过敏反应）。硫酸镍的反应指数为0.91，但重铬酸钾的反应指数仅为0.23，这是因为可疑反应明显更多。总之，使用标准化良好的斑贴试验系统，尤其是硫酸镍，可实现结果的高度同步可重复性。然而，不同的变应原和测试系统需要分别进行评估。
