Ritzkowsky A, Weissenborn S, Krieg T, Pfister H, Wieland U
Department of Dermatology, University of Cologne, Germany.
Acta Derm Venereol. 2001 May;81(2):130-3. doi: 10.1080/00015550152384281.
Human papillomavirus (HPV) type 7 is frequently found in butchers' warts and has been demonstrated in oral and facial warts of HIV-infected patients. The reservoirs of HPV7 and the route of transmission are still unclear. Here we describe an HIV-negative, otherwise healthy patient with extensive, recurrent orofacial papillomatosis whose immune status proved to be normal and who had no history of meat handling. HPV7 L1 gene DNA that differed in 3 point mutations from the HPV7 prototype could be detected in 2 morphologically distinct, perioral lesions by different PCR protocols. In situ hybridization confirmed the presence of HPV7 DNA in the nuclei of vacuolated cells of the granular layer. Our data show that HPV7 can lead to perioral, spiky warts and brownish plaques in immunocompetent patients who had never been working as a meat or fish handler.
人乳头瘤病毒7型（HPV7）常见于屠夫疣，并且在HIV感染患者的口腔和面部疣中也有发现。HPV7的储存宿主和传播途径仍不清楚。在此，我们描述了一名HIV阴性、其他方面健康的患者，该患者患有广泛的、复发性口腔面部乳头状瘤病，其免疫状态正常且无肉类处理史。通过不同的PCR方案，在两个形态不同的口周病变中检测到与HPV7原型在3个点突变上不同的HPV7 L1基因DNA。原位杂交证实颗粒层空泡化细胞核中存在HPV7 DNA。我们的数据表明，HPV7可导致从未从事肉类或鱼类处理工作的免疫功能正常患者出现口周、尖状疣和褐色斑块。
