Sapriel G
Département des biotechnologies, Institut Pasteur, Paris, France.
Res Microbiol. 2001 Jul-Aug;152(6):531-8. doi: 10.1016/s0923-2508(01)01227-x.
Two unusual phenotypes in Saccharomyces cerevisiae, [PSI+] and [URE3], have been suggested to be due to prion proteins. Various research groups have shown that this is indeed the case and have characterized these yeast prions in more detail. The factors involved in prion formation, such as chaperone protein, and the intramolecular determinants of prion formation have been investigated. The ability of these yeast proteins to form prion is due to modular domains conserved throughout evolution.
酿酒酵母中的两种异常表型，即[PSI+]和[URE3]，被认为是由朊病毒蛋白引起的。多个研究小组已经证明确实如此，并对这些酵母朊病毒进行了更详细的表征。人们对参与朊病毒形成的因素，如伴侣蛋白，以及朊病毒形成的分子内决定因素进行了研究。这些酵母蛋白形成朊病毒的能力归因于在整个进化过程中保守的模块化结构域。
