Dittrich R, Recabarren S, Mitze M, Jaeger W
Department of Obstetrics and Gynecology, University of Erlangen-Nuremberg, Erlangen, Germany.
J Cancer Res Clin Oncol. 2001 Aug;127(8):495-501. doi: 10.1007/s004320100251.
In this study the effect of continuous stimulation of gonadotropins on sex cord stromal tumors in the rat was examined.
Sex cord stromal tumors were induced by transplantation of ovaries under the splenic capsule of ovariectomized rats. Beginning 180 days after transplantation, these tumors were taken out and cut into several pieces, which were then retransplanted (by isotransplantation) under the splenic capsule of 80 either intact or ovariectomized rats.
Most of the tumor grafts grew up to a median size of 0.7 cm in ovariectomized rats. However, some of the tumors recovered from recipient rats that were retransplanted with donor tumors differed significantly from the others. Characterized by a high mitotic rate, nuclear atypia, size (up to 3.8 cm) as well as growth in intact animals, these tumors were defined as malignant. They could be kept in culture and always led to the development of metastases after retransplantation into other rats.
Benign sex cord stromal tumors can show malignant growth after transplantation. This study for the first time demonstrates that gonadotropins are involved in the induction of ovarian malignancies.
本研究检测了促性腺激素持续刺激对大鼠性索间质肿瘤的影响。
通过将卵巢移植到去卵巢大鼠的脾包膜下诱导性索间质肿瘤。移植后180天开始，取出这些肿瘤并切成数块，然后将其（通过同基因移植）重新移植到80只完整或去卵巢大鼠的脾包膜下。
在去卵巢大鼠中，大多数肿瘤移植物生长至中位大小为0.7厘米。然而，从接受供体肿瘤重新移植的受体大鼠中恢复的一些肿瘤与其他肿瘤有显著差异。这些肿瘤以高有丝分裂率、核异型性、大小（可达3.8厘米）以及在完整动物中的生长为特征，被定义为恶性肿瘤。它们可以在培养中保存，并且在重新移植到其他大鼠后总是会导致转移的发生。
良性性索间质肿瘤在移植后可表现出恶性生长。本研究首次证明促性腺激素参与卵巢恶性肿瘤的诱导。
