Lumachi F, Ferretti G, Povolato M, Marzola M C, Zucchetta P, Geatti O, Bui F, Brandes A A
Department of Surgical and Gastoenterological Sciences, University of Padua, School of Medicine, Padova, Italy.
Anticancer Res. 2001 May-Jun;21(3C):2201-5.
The aim of this study was to compare the results obtained using X-ray mammography (MG) and 99mTc-sestamibi scintimammography (SSM) in patients with breast lesions < or = 2 cm. One hundred and thirty-four women (median age 52 years, range 32-78), who had already been selected for open breast biopsy, underwent both MG and SSM prior to surgery. Final pathology showed 27 (20.1%) benign breast lesions and 107 (79.9%) breast cancers (pT1a=5 [4.7%], pT1b=50 [46.7%], pT1c=52 [48.6%]). The sensitivity, positive predictive value, negative predictive value and accuracy were 81.3%, 97.6%, 55.6% and 83.6% for SSM and 83.2%, 89.9%, 48.6% and 79.1% for MG, respectively. The results were similar (p=NS), but patients with breast cancer (BC) undetected by MG were significantly (p<0.05) younger than those in which the tumor was correctly diagnosed, while the age did not affect SSM sensitivity. SSM was more (p<0.05) specific than MG in BC detection both in the overall group of patients (92.6% vs 63.0%) and in those with < or = 10 mm breast lesions (94.7% vs 63.2%). In conclusion, in patients with suspected BC sized < or = 2 cm, SSM may help in surgical planning because of its high specificity, and should be considered complementary to MG, especially in younger women.
本研究旨在比较X线乳腺摄影（MG）和99mTc-甲氧基异丁基异腈闪烁乳腺造影（SSM）在乳腺病变≤2 cm患者中的检查结果。134名女性（中位年龄52岁，范围32 - 78岁）已被选定接受开放性乳腺活检，在手术前均接受了MG和SSM检查。最终病理显示27例（20.1%）为良性乳腺病变，107例（79.9%）为乳腺癌（pT1a = 5例[4.7%]，pT1b = 50例[46.7%]，pT1c = 52例[48.6%]）。SSM的敏感性、阳性预测值、阴性预测值和准确性分别为81.3%、97.6%、55.6%和83.6%，MG的分别为83.2%、89.9%、48.6%和79.1%。结果相似（p = 无统计学意义），但MG未检测出乳腺癌（BC）的患者明显（p < 0.05）比肿瘤被正确诊断的患者年轻，而年龄不影响SSM的敏感性。在整个患者组（92.6%对63.0%）以及乳腺病变≤10 mm的患者中（94.7%对63.2%），SSM在BC检测方面比MG更具特异性（p < 0.05）。总之，在疑似BC大小≤2 cm的患者中，SSM因其高特异性可能有助于手术规划，应被视为MG的补充检查，尤其是在年轻女性中。
