Shiau Y C, Tsai S C, Ho Y J, Kao C H
Department of Nuclear Medicine, Far Eastern Memorial Hospital, and Institute of Biomedical Engineering, College of Electrical Engineering, National Taiwan University, Taipei.
Anticancer Res. 2001 May-Jun;21(3C):2213-7.
The diagnostic accuracy of technetium-99m methoxyisobutylisonitrile (Tc-MIBI) single photon emission computed tomography (SPECT) of head and neck to differentiate between recurrent or residual nasopharyngeal carcinomas (NPC) and benign lesions after radiotherapy was evaluated, and compared with computed tomography (CT). Thirty-six NPC patients 4 months after radiotherapy underwent Tc-MIBI SPECT and CT of head and neck, as well as histopathological examination of nasopharyngeal biopsies. Based on the biopsy results, the sensitivity, specificity, and accuracy of CT were 73%, 88%, and 83%, respectively. The sensitivity, specificity, and accuracy of Tc-MIBI SPECT were 64%, 96%, and 86%, respectively. The sensitivity, specificity, and accuracy of combined Tc-MIBI SPECT and CT were 100%, 88%, and 92%, respectively. Tc-MIBI SPECT had a better specificity and a lower sensitivity to differentiate benign lesions from recurrent/residual NPC when compared with CT The combined use of CT and Tc-MIBI SPECT significantly increased accuracy compared with the single use of either Tc-MIBI SPECT or CT to differentiate benign lesions recurrent/residual NPC.
评估了锝-99m甲氧基异丁基异腈（Tc-MIBI）单光子发射计算机断层扫描（SPECT）对头颈部进行检查以鉴别鼻咽癌（NPC）放疗后复发或残留与良性病变的诊断准确性，并与计算机断层扫描（CT）进行比较。36例放疗后4个月的NPC患者接受了头颈部Tc-MIBI SPECT和CT检查，以及鼻咽活检的组织病理学检查。根据活检结果，CT的敏感性、特异性和准确性分别为73%、88%和83%。Tc-MIBI SPECT的敏感性、特异性和准确性分别为64%、96%和86%。Tc-MIBI SPECT与CT联合检查的敏感性、特异性和准确性分别为100%、88%和92%。与CT相比，Tc-MIBI SPECT在鉴别良性病变与复发/残留NPC方面具有更好的特异性和更低的敏感性。与单独使用Tc-MIBI SPECT或CT鉴别良性病变与复发/残留NPC相比，CT和Tc-MIBI SPECT联合使用显著提高了准确性。
