Tsai Ming-Hsui, Huang Wen-Sheng, Tsai Jeffrey J, Chen Yen-Kung, Changlai Shen-Pin, Kao Chia-Hung
Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan.
Anticancer Res. 2003 Jul-Aug;23(4):3513-6.
The aim of this study was to compare the accuracy of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) and thallium-201 (Tl-201) single photon emission computed tomography (SPECT) in differentiating recurrent/residual nasopharyngeal carcinomas (NPC) from post-radiotherapy (RT) changes in patients with indeterminate computed tomography (CT) findings. Twenty NPC patients with indeterminate CT findings were included at least 4 months after RT. CT, FDG-PET, Tl-201 SPECT and biopsy were performed within 1 week. The final diagnoses were based on biopsy findings and clinical follow-up for at least 6 months. For differentiating recurrent/residual NPC from post-RT changes in patients with indeterminate CT findings, the sensitivity, specificity and accuracy of FDG-PET were 100.0%, 92.3% and 96.0%, respectively. The sensitivity, specificity and accuracy of Tl-201 SPECT were 91.7%, 92.3% and 92.0%, respectively. Based on this study's findings, we can conclude FDG-PET is more sensitive but equally specific as Tl-201 SPECT is differentiating recurrent/residual NPC from post-RT changes in patients with indeterminate CT findings.
本研究的目的是比较18-氟-2-脱氧葡萄糖（FDG）正电子发射断层扫描（PET）和铊-201（Tl-201）单光子发射计算机断层扫描（SPECT）在鉴别计算机断层扫描（CT）结果不确定的患者中复发性/残留性鼻咽癌（NPC）与放疗后（RT）改变方面的准确性。纳入20例CT结果不确定的NPC患者，均在放疗后至少4个月。在1周内进行CT、FDG-PET、Tl-201 SPECT及活检。最终诊断基于活检结果及至少6个月的临床随访。对于鉴别CT结果不确定的患者中复发性/残留性NPC与放疗后改变，FDG-PET的敏感性、特异性及准确性分别为100.0%、92.3%及96.0%。Tl-201 SPECT的敏感性、特异性及准确性分别为91.7%、92.3%及92.0%。基于本研究结果，我们可以得出结论，在鉴别CT结果不确定的患者中复发性/残留性NPC与放疗后改变方面，FDG-PET比Tl-201 SPECT更敏感，但特异性相当。
