Rossi M L, Merlini P A, Ardissino D
A. De Gasperis Cardiology Department, Hospital Niguarda Ca' Granda, Milan, Italy.
Ital Heart J. 2001 Jul;2(7):490-4.
Investigations carried out over the last 40 years have demonstrated that coronary artery thrombosis is the critical event underlying myocardial infarction and unstable angina. The existence of a prolonged hypercoagulable state preceding the thrombotic event has been postulated for some time and significant associations have been established between the plasma concentrations of a number of hemostatic variables and the frequency of myocardial infarction. High plasma fibrinogen, factor VII/VIIa, tissue-type plasminogen activator and plasminogen activator inhibitor levels have been associated with at least as great a risk of developing myocardial (re)infarction or sudden death as high cholesterol levels, especially in the young. In the last year more sensitive assays have been developed, and they should allow a precise biochemical definition of hypercoagulable states. The significance of these new assays and their role in defining a hypercoagulable state in different conditions are analyzed.
过去40年所做的研究表明，冠状动脉血栓形成是心肌梗死和不稳定型心绞痛的关键事件。血栓形成事件之前存在长期高凝状态这一假设已提出一段时间，并且已经确定了许多止血变量的血浆浓度与心肌梗死发生率之间的显著关联。高血浆纤维蛋白原、因子VII/VIIa、组织型纤溶酶原激活物和纤溶酶原激活物抑制剂水平与高胆固醇水平至少具有同样大的发生心肌（再）梗死或猝死的风险，尤其是在年轻人中。去年开发出了更灵敏的检测方法，这些方法应能对高凝状态进行精确的生化定义。本文分析了这些新检测方法的意义及其在不同情况下定义高凝状态中的作用。
