Geelhoed D W, Visser L E, Addae V, Asare K, Schagen van Leeuwen J H, van Roosmalen J
Primary Health Care Department, Holy Family Hospital, Berekum, Ghana.
Int J Gynaecol Obstet. 2001 Aug;74(2):133-8. doi: 10.1016/s0020-7292(01)00419-2.
To assess the effect of introducing chloroquine prophylaxis during pregnancy on prevalence of anemia (<10.9 g/dl) at childbirth and perinatal outcome.
Observational study in a rural district hospital in Ghana, which compared 2803 women who received chloroquine prophylaxis during pregnancy with 3084 historical controls, who had not received prophylaxis during pregnancy. Main outcome measures were hemoglobin level at childbirth, perinatal mortality and birth weight.
Mean hemoglobin level before childbirth increased from 10.7 g/dl (S.D.=1.0 g/dl) to 11.0 g/dl (S.D.=0.9 g/dl). Prevalence of anemia decreased from 29.4 to 13.3% (OR=0.4 and 95% CI=0.3-0.4). Prevalence of moderately severe anemia (<9.0 g/dl) decreased from 4.4 to 3.3% (OR=0.7, 95% CI=0.6-0.97). Perinatal mortality and low birth weight (<2500 g) remained unchanged.
Routine chloroquine prophylaxis in pregnancy is useful in reducing anemia at childbirth in malaria-endemic regions. Fetal outcome did not improve with chloroquine prophylaxis in this study.
评估孕期采用氯喹预防措施对分娩时贫血（血红蛋白<10.9 g/dl）患病率及围产期结局的影响。
在加纳一家农村地区医院开展观察性研究，比较了2803名孕期接受氯喹预防措施的女性与3084名历史对照者（孕期未接受预防措施）。主要观察指标为分娩时的血红蛋白水平、围产期死亡率及出生体重。
分娩前平均血红蛋白水平从10.7 g/dl（标准差=1.0 g/dl）升至11.0 g/dl（标准差=0.9 g/dl）。贫血患病率从29.4%降至13.3%（比值比=0.4，95%置信区间=0.3 - 0.4）。中度严重贫血（血红蛋白<9.0 g/dl）患病率从4.4%降至3.3%（比值比=0.7，95%置信区间=0.6 - 0.97）。围产期死亡率及低出生体重（<2500 g）未发生变化。
孕期常规使用氯喹预防措施有助于降低疟疾流行地区分娩时的贫血发生率。在本研究中，氯喹预防措施未改善胎儿结局。
