Patterson R, Harris K E
Int Arch Allergy Appl Immunol. 1975;49(3):381-90. doi: 10.1159/000231419.
The immediate-type airway response in anesthetized dogs and rhesus monkeys to two antigens (ascaris and keyhole limpet hemocyanin) and pharmacologic agents (histamine, methacholine and prostaglandin F2alpha) were studied. The pulmonary function abnormalities demonstrated by changes in breathing frequency, peak expiratory flow rate, pulmonary resistance, expiratory-inspiratory time ratio, tidal volume, and dynamic compliance were compared with simultaneous determinations of arterial pO2, muscle pO2 or both, using indwelling electrodes. The results demonstrate that the O2 determinations provide an additional parameter of study of these experimental models of asthma, and that it may be one of the more sensitive indicators of an induced airway response of the immediate-type. The hypoxia parallels the degree of severity of the respiratory response and demonstrates a further similarity of this model to human asthma.
研究了麻醉犬和恒河猴对两种抗原（蛔虫和钥孔戚血蓝蛋白）以及药理剂（组胺、乙酰甲胆碱和前列腺素F2α）的速发型气道反应。通过呼吸频率、呼气峰值流速、肺阻力、呼气-吸气时间比、潮气量和动态顺应性的变化所显示的肺功能异常，与使用留置电极同时测定的动脉血氧分压、肌肉血氧分压或两者进行了比较。结果表明，血氧测定为这些哮喘实验模型的研究提供了一个额外的参数，并且它可能是速发型诱导气道反应的更敏感指标之一。低氧与呼吸反应的严重程度平行，并且表明该模型与人类哮喘还有进一步的相似性。
