Tavintharan S, Mukherjee J J
Department of Medicine, Changi General Hospital.
Ann Acad Med Singap. 2001 Jul;30(4):436-9.
Hypoglycaemic episodes in patients with diabetes mellitus are mostly due to excess doses of exogenous insulin or oral hypoglycaemic agents, coupled with poor caloric intake and excessive unplanned physical exertion. Hypoglycaemia as a result of endogenous hyperinsulinaemia due to an insulinoma is extremely rare in such patients.
This patient with type 2 diabetes mellitus presented with episodes of syncope. Investigations confirmed recurrent hypoglycaemia from endogenous hyperinsulinaemia, with localisation of a tumour in the tail of the pancreas.
Distal pancreatectomy and splenectomy. Histology confirmed an insulinoma.
No further hypoglycaemic episodes were noted. The patient returned to his diabetic state with rather poor glycaemic control.
Repeated hypoglycaemic episodes in a patient with diabetes mellitus despite complete withdrawal of hypoglycaemic agents should lead one to consider other causes of hypoglycaemia.
糖尿病患者的低血糖发作大多是由于外源性胰岛素或口服降糖药剂量过大,加上热量摄入不足和意外过度体力活动所致。因胰岛素瘤导致内源性高胰岛素血症引起的低血糖在这类患者中极为罕见。
该2型糖尿病患者出现晕厥发作。检查证实因内源性高胰岛素血症反复发生低血糖,肿瘤定位于胰尾。
胰体尾切除术和脾切除术。组织学检查证实为胰岛素瘤。
未再出现低血糖发作。患者恢复糖尿病状态,但血糖控制较差。
糖尿病患者在完全停用降糖药后仍反复出现低血糖发作,应考虑低血糖的其他原因。