Miñambres García E, Antolínez Eizaguirre X, Infante Ceberio J, Rodríguez Borregán J C, Iribarren Sarrías J L, Tejido García R, Ugarte Peña P
Departamento de Medicina Intensiva, Hospital Universitario Marqués de Valdecilla, Avenida Valdecilla, s/n. 39008 Santander.
An Med Interna. 2001 Jun;18(6):294-7.
The generalized convulsive status epilepticus (GCSE) is a medical emergency with a high morbimortality rate. We analyzed the casuistry in our hospital and we assessed the causes related to mortality.
This is a retrospective study of 57 cases of GCSE that took place between january 1992 to december 1998. The variables studied were mortality among groups according to age, previous epilepsy and the duration of the convulsive episode.
We found male prevalence (63.2%). The 49.2% of patients didn't have previous history of epilepsy. In 38.6% of cases the treatment dose was insufficient and in 61.4% it was delated. The mortality rate was 36.8% with a higher significance in patients older than 65 (p < 0.02), without previous history of epilepsy (p < 0.001) and in episodes lasting more than 4 hours (p < 0.05). Only 12.9% of patients received prehospital treatment.
The mortality of GCSE is very high. The initial treatment is inadequate. We must establish a premature and adequate protocol, with optim pharmacological doses and a good coordination with intensive care units.
全身性惊厥性癫痫持续状态（GCSE）是一种死亡率很高的医疗急症。我们分析了我院的病例情况，并评估了与死亡率相关的原因。
这是一项对1992年1月至1998年12月期间发生的57例GCSE病例的回顾性研究。所研究的变量包括根据年龄、既往癫痫史和惊厥发作持续时间分组的死亡率。
我们发现男性患病率为（63.2%）。49.2%的患者既往无癫痫病史。38.6%的病例治疗剂量不足，61.4%的病例治疗延迟。死亡率为36.8%，在65岁以上患者（p < 0.02）、无癫痫病史患者（p < 0.001）以及发作持续超过4小时的患者中（p < 0.05）具有更高的显著性。只有12.9%的患者接受了院前治疗。
GCSE的死亡率非常高。初始治疗不充分。我们必须制定一个早期且充分的方案，采用最佳药物剂量，并与重症监护病房进行良好协调。
