Chen W J, Parnell S E, West J R
Department of Human Anatomy & Medical Neurobiology, College of Medicine, The Texas A&M University System Health Science Center, College Station, Texas 77843-1114, USA.
Alcohol Clin Exp Res. 2001 Jul;25(7):1072-7.
Our previous findings suggested that the intragastric coadministration of alcohol and nicotine to neonatal rats resulted in a significant decrease from the predicted peak blood alcohol concentration (BAC). We hypothesized that the coadministration of alcohol and nicotine would produce a nicotine dose-related decrease in peak BAC and a change in the BAC time curve profile.
Sprague-Dawley rat pups were given alcohol and nicotine simultaneously via intragastric infusion. Two sets of nicotine doses were used in two independent studies. The low doses of nicotine were examined after the study of high doses of nicotine administration because of the possible ceiling effects from these nicotine doses on lowering BACs.
The results not only confirmed that the peak BAC was lowered by nicotine, but also generated new findings showing that the profile of BAC time curve was affected by these doses of nicotine. Concerns about possible ceiling effects led us to conduct another experiment to examine the effects of lower doses of nicotine on BACs. Those results showed a significant decline in BACs after cotreatment with 0.5 or 1 mg/kg nicotine and less robust changes on the BAC curve profiles. Although the nicotine dose at 0.25 mg/kg/day did not affect significantly the overall BAC profile, it did lower the peak BAC.
Nicotine is capable of lowering the peak BAC among neonatal rat pups. Furthermore, the pattern of the BAC time curve seems to be more affected by high doses of nicotine.
我们之前的研究结果表明，给新生大鼠胃内同时给予酒精和尼古丁会导致实际血酒精浓度峰值（BAC）显著低于预测值。我们推测，酒精和尼古丁同时给药会使BAC峰值出现与尼古丁剂量相关的下降，并改变BAC时间曲线的形态。
通过胃内灌注法同时给予斯普拉格-道利大鼠幼崽酒精和尼古丁。在两项独立研究中使用了两组尼古丁剂量。由于高剂量尼古丁对降低BAC可能存在天花板效应，因此在研究高剂量尼古丁给药后，又对低剂量尼古丁进行了研究。
结果不仅证实尼古丁降低了BAC峰值，还产生了新的发现，即这些剂量的尼古丁影响了BAC时间曲线的形态。由于担心可能存在天花板效应，我们又进行了另一项实验，以研究低剂量尼古丁对BAC的影响。结果显示，与0.5或1mg/kg尼古丁联合处理后，BAC显著下降，且BAC曲线形态变化较小。虽然0.25mg/kg/天的尼古丁剂量对整体BAC形态没有显著影响，但确实降低了BAC峰值。
尼古丁能够降低新生大鼠幼崽的BAC峰值。此外，高剂量尼古丁似乎对BAC时间曲线的形态影响更大。
